Title:
新規なIFN受容体1結合タンパク質、それらをコードするDNA、およびインターフェロンに対する細胞応答の調節方法
Document Type and Number:
Japanese Patent JP4614473
Kind Code:
B2
Abstract:
Novel proteins IR1B1 and IR1B4 have been isolated which bind to the type I IFN receptor IFNAR1 and function in the cellular response to IFNs. DNA encoding such proteins in either the sense or anti-sense orientation can be administered to either enhance or inhibit the cellular response to IFNs. Antibodies to the proteins can be used for isolation of the new protein or for immunodetection thereof.
Inventors:
Level, mikle
Abramovic, Carolina
Chebas, Judith Y
Abramovic, Carolina
Chebas, Judith Y
Application Number:
JP53237098A
Publication Date:
January 19, 2011
Filing Date:
January 15, 1998
Export Citation:
Assignee:
Yeda Research and Development Company Limited
International Classes:
C12N15/09; A61K31/80; A61K38/21; A61K48/00; A61P35/00; A61P37/00; A61P43/00; C07K14/47; C07K14/715; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/00; C12N5/10; C12N9/10; C12N15/12; C12N15/63; A61K38/00
Other References:
NCBI sequence HSU83236,Human Snk interacting protein 2-28 mRNA, 1997年 1月 2日
NIKAWA Jun-ichi et al., Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant, gene, 1996年 1月, 171(1), pp.107-111
NIKAWA Jun-ichi et al., Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant, gene, 1996年 1月, 171(1), pp.107-111
Attorney, Agent or Firm:
Kawamura Taku
Yousuke Fujimori
Seiji Tani
Kei Saki
Yousuke Fujimori
Seiji Tani
Kei Saki