Title:
新規なTRPA1アンタゴニスト
Document Type and Number:
Japanese Patent JP2013507364
Kind Code:
A
Abstract:
The present invention relates to compositions and methods that modulate at least one TRP family member. Specifically, the present invention relates to novel TRPA1 antagonists and their use in the treatment of pain such as chronic inflammatory and neuropathic pain. Compounds that can modulate one or more TRPA1 functions are useful in many aspects including, but not limited to, maintaining calcium homeostasis; maintaining sodium homeostasis; modulating intracellular calcium levels; modulating membrane polarization (membrane potential); modulating cation levels; and/or treating or preventing diseases, disorders, or conditions associated with calcium homeostasis, sodium homeostasis, calcium or sodium dyshomeostasis, or membrane polarization/hyperpolarization (including hypo and hyperexcitability), and/or treating or preventing diseases, disorders, or conditions associated with regulation or misregulation of TRPA1 expression or function. The present invention further relates to methods and compositions that antagonize both a function of TRPA1 and a function of one or more additional TRP channels.
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Inventors:
Bilodo, Mark Tay
Egbertson, Melitsa
Green,arlen
Lee, Eway
Heartnet, Jiyoung Shee
Egbertson, Melitsa
Green,arlen
Lee, Eway
Heartnet, Jiyoung Shee
Application Number:
JP2012533207A
Publication Date:
March 04, 2013
Filing Date:
September 28, 2010
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07C215/44; A61K31/136; A61K31/277; A61K31/352; A61K31/353; A61K31/47; A61P25/04; A61P43/00; C07C255/58; C07D215/38; C07D215/44; C07D311/74; C07D311/76; C07K14/705
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama