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Title:
NEW AMYLOID-AFFINITIVE COMPOUND
Document Type and Number:
Japanese Patent JP2009120591
Kind Code:
A
Abstract:

To provide a compound which is effective as a probe for image diagnosis targeting amyloid, and to provide a reagent containing the compound and used for detecting amyloid deposited in living body tissues.

The compound is represented by formula, wherein, R1 is a radioactive halogen substituent; (m) is an integer of 1 to 4, and the reagent containing the compound and used for detecting amyloid deposited in living body tissues. The compound has affinity to amyloid deposited in living body tissues, and has a good clearance from normal tissues. The compound can be suitably used for providing a new amyloid-affinitive compound having a good amyloid-detecting ability in living bodies, and a reagent for detecting the amyloid deposited in living body tissues.


Inventors:
TANIFUJI SHIGEYUKI
NAKAMURA DAISAKU
TAKASAKI SHINYA
OKUMURA YUKI
Application Number:
JP2008269517A
Publication Date:
June 04, 2009
Filing Date:
October 20, 2008
Export Citation:
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Assignee:
NIHON MEDIPHYSICS CO LTD
International Classes:
A61K51/00; C07D471/04
Domestic Patent References:
JPS5289689A1977-07-27
Foreign References:
WO2007063946A12007-06-07
Other References:
JPN6013027922; Tetrahedron Letters (2003), 44(33), 6265-6267