Title:
新規のフルオロエルゴリン類似体
Document Type and Number:
Japanese Patent JP2014517076
Kind Code:
A
Abstract:
Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
Inventors:
Cook, Robert Oh.
Zhang, Jiang
Armor, Thomas A.
Zhang, Jiang
Armor, Thomas A.
Application Number:
JP2014517195A
Publication Date:
July 17, 2014
Filing Date:
June 22, 2012
Export Citation:
Assignee:
Map Pharmaceuticals Incorporated
International Classes:
C07D519/00; A61K31/48; A61P25/06; A61P43/00
Domestic Patent References:
| JPS562992A | 1981-01-13 | |||
| JPS5331698A | 1978-03-25 | |||
| JPS4886900A | 1973-11-15 | |||
| JPS478777A | ||||
| JPS62190184A | 1987-08-20 |
Foreign References:
| US4005089A | 1977-01-25 | |||
| US20110152280A1 | 2011-06-23 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office