To provide a new peptide utilizable as a nephrotoxicity inhibitor, to provide the nephrotoxicity inhibitor given by using the same, and to provide an antibacterial preparation given by using the same.
This basic peptide contains three or more basic amino acids which are sequentially arranged in a molecule thereof, wherein amino acids arranged in regions intervening between the basic amino acids in the molecule comprise neutral amino acids or basic amino acids. Then, a peptide comprising an amino acid sequence expressed by sequence number 1 is synthesized as the basic peptide, and further a renal epithelial cell to which the peptide and [3H]gentamycin are added is cultured. The peptide thus synthesized has an IC50 value of 2.1 μM and it is confirmed that an inhibitory effect of the peptide on taking-up of the gentamycin is 18 times or more larger than the effect conventionally confirmed.
NAGAI JUNYA
MURAKAMI TERUO
| JP2003261459A | 2003-09-16 | |||
| JP2003504395A | 2003-02-04 |