Title:
新規ピリミジン誘導体
Document Type and Number:
Japanese Patent JP2010520187
Kind Code:
A
Abstract:
The invention concerns compounds of Formula I, or a pharmaceutically acceptable salt thereof, where R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.
Inventors:
Ashton, Susan Elizabeth
Barlam, Bernardo Christoph
Cross, Darren Anthony Edward
Ducray, Richard
East, Simon John
Kettle, Jason Grant
Pearson, Mark Andrew
Stuart Charles, Perkis
Stephen Robert Wedge
Barlam, Bernardo Christoph
Cross, Darren Anthony Edward
Ducray, Richard
East, Simon John
Kettle, Jason Grant
Pearson, Mark Andrew
Stuart Charles, Perkis
Stephen Robert Wedge
Application Number:
JP2009551260A
Publication Date:
June 10, 2010
Filing Date:
February 27, 2008
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D239/48; A61K31/506; A61K31/5377; A61K31/541; A61K31/553; A61P35/00; A61P35/02; A61P43/00; C07D401/12; C07D405/12; C07D413/12; C07D491/113
Domestic Patent References:
| JP2005527529A | 2005-09-15 |
Foreign References:
| WO2005026130A1 | 2005-03-24 | |||
| WO2005026158A1 | 2005-03-24 |
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi