Title:
新規な四価の二重特異性抗体
Document Type and Number:
Japanese Patent JP2008512352
Kind Code:
A
Abstract:
The invention is directed to novel tetravalent antibodies, which are preferably bi-specific. The tetravalent bispecific antibodies can be efficiently expressed in prokaryotic and eukaryotic cells, and are useful in therapeutic and diagnostic methods. The invention further describes administration of the antibodies, either alone or in combination with antiangiogenic or anti-neoplastic drugs to inhibit tumor growth and/or angiogenesis.
Inventors:
Ju, Chen Ping
Application Number:
JP2007521716A
Publication Date:
April 24, 2008
Filing Date:
July 18, 2005
Export Citation:
Assignee:
CORNELL RESEARCH FOUNDATION, INCORPORATED
International Classes:
C07K16/46; A61K38/00; A61P35/00; A61P43/00; C07K16/28; C07K16/40; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazumi Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazumi Nakamura