Title:
エストロゲン受容体に対する非ステロイド系リガンド
Document Type and Number:
Japanese Patent JP4417548
Kind Code:
B2
Abstract:
Triphenyl-alkene derivatives of formula (I) are new. R1 = (CH2)nCR5=CR6R7; R2, R3 = H, Me, OH, OMe, OEt or i-Pr; R4 = CN, NO2, Me, Et, CH2CH2Y or Y; R5, R6 = H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, X-(1-3C)alkyl, X-(2-4C)alkenyl, X-(2-4C)alkynyl or Y; R7 = CN, 1-4C hydroxyalkyl, CONR10R11, CONR12R13, CONHCH2R12, C(NH2)NOR12, SOR12, SO2OR12, SO2NHCO2R12, PO3R12, PO(NR12R13)(NR12R13), PO(NR12R13)(OR14), CONR12(CH2)qOMe, CONR12(CH2)qNR8R9 or oxadiazolyl substituted with Me; R8, R9 = H, 1-7C alkyl, 3-7C cycloalkyl, 1-7C alkoxy, (1-7C)alkyl-Y or phenyl; R10, R11 = Me or Et; or NR10R11 = morpholino; R12-R14 = H, 1-12C alkyl, 2-12C alkenyl, 2-12C alkynyl, 1-12C alkoxy, 2-12C alkenyloxy, 2-12C alkynyloxy, 3-7C cycloalkenyl, 3-7C cycloalkenyl (sic), linear and cyclic heteroalkyl, aryl, heteroaryl or Y; X = O or S; Y = halo; n = 0-2; and q = 1-12.
Inventors:
Wilson, Timothy Mark
Application Number:
JP2000507204A
Publication Date:
February 17, 2010
Filing Date:
August 12, 1997
Export Citation:
Assignee:
Glaxo Welcome Incorporated
International Classes:
C07C33/28; A61K31/135; C07D295/08; A61K31/137; A61K31/165; A61K31/215; A61K31/275; A61K31/41; A61K31/4245; A61K31/5375; A61K31/5377; A61P9/00; A61P19/02; A61P19/10; A61P35/00; C07C45/45; C07C45/59; C07C47/548; C07C49/796; C07C57/42; C07C57/48; C07C69/618; C07C211/28; C07C233/10; C07C233/11; C07C233/22; C07C233/40; C07C233/44; C07C233/58; C07C251/40; C07C255/07; C07C255/34; C07C327/44; C07D271/06; C07D295/185; C07F9/40; C07C
Domestic Patent References:
| JP9328421A | ||||
| JP10510840A | ||||
| JP10506111A |
Other References:
Journal of the American Chemical Society,1996年,118(26),p.6331-6332
Journal of Medicinal Chemistry,1994年,37(11),p.1550-1552
Journal of Steroid Biochemistry,1989年,34(1-6),p.407-411
Journal of Medicinal Chemistry,1994年,37(11),p.1550-1552
Journal of Steroid Biochemistry,1989年,34(1-6),p.407-411
Attorney, Agent or Firm:
Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto
Toshio Shirane
Sadao Muramatsu
Ryo Hashimoto
Toshio Shirane