Title:
NONHUMAN CHIMERA CELL
Document Type and Number:
Japanese Patent JP2718596
Kind Code:
B2
Abstract:
PURPOSE: To obtain a nonhuman chimera mammal which is obtained by transplanting cells or tissues other than normal hemopoietic cells derived from a mammal M3 to a mammal M1 that is substituted by hemopoietic cells derived from a mammal M2, and has nonhuman chimera cells stable over a long period.
CONSTITUTION: The objective nonhuman chimera mammal M4 used for stably supplying the objective nonhuman chimera cells, is obtained by: treating a nonhuman mammal M1 (ordinary mouse) so as to substantially destroy its immunity system; transplanting tissues or cells (such as human malignant tumor cells) other than normal hemopoietic cells derived from a mammal M3 (human being) to the treated nonhuman mammal M1; and further transplanting hemopoietic cells derived from a mammal M2 (such as serious complex immunodeficiency syndrome mouse) that is a species other than the mammal M3 and determined as a genetically hemopoietic-cell-deficient mammal, to the resulting nonhuman mammal M1.
Inventors:
Yayer Reisner
Application Number:
JP14456892A
Publication Date:
February 25, 1998
Filing Date:
June 04, 1992
Export Citation:
Assignee:
Yeda Research and Development Company Limited
International Classes:
A01K67/027; A61K35/28; A61K35/38; A61K35/407; C07K16/10; C12N5/10; G01N33/15; (IPC1-7): A01K67/027; G01N33/15
Other References:
【文献】Journal of Experimental Medicine 172 p.1055(1990)
Attorney, Agent or Firm:
Akira Asamura (3 outside)