To pursue temperature-induced glycolysis in the noninvasive measurement of glucose.
The change of glucose metabolism inside a skin nutrition capillary tube is induced, the change of localized reflectance optical signals in a plurality of distances between a light source and a detector and a plurality of wavelengths is measured as the function of the time of bringing a probe into contact with the skin, a time window capable of minimizing the influence of tissue and probe adaptation on signals is selected, and also the signals measured within the time window are used for the following calculation. One set of functions is calculated from a plurality of localized reflectance values in the plurality of distances between the light source and the detector and the plurality of wavelengths at a plurality of time intervals in at least two wavelengths within the time window, calibration relation between the combination of calculation functions and the glucose concentration of a living body is derived, and the calibration relation is used in order to predict the glucose concentration in body liquid in the following measurement.
KHALIL OMAR S
JENG TZYY-WEN
YEH SHU-JEN
ABBOTT LAB
| JP2004535213A | 2004-11-25 |
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto
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