ノロウイルス抗原およびサポウイルス抗原

Japanese Patent JP5215865

B2

Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.

Koito, Doris
Houghton, Michael
McCoin, Colin
Medina-Selby, Angelica
Bachdi, Michael

JP2008542449A

June 19, 2013

November 22, 2006

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Novartis Vaxins And Diagnostics Incorporated

C12N15/09; C07K14/08; C12N1/19; C12N7/00; C12P21/02

WO2005032457A1
WO2002036172A1

BALL J M,ARCHIVES OF VIROLOGY,オーストリア,SPRINGER-VERLAG,1996年,V12 SUPPL,P243-249
Vaccine,2004年,Vol.22,p.1079-1086
J Gen Virol.,1997年,Vol.78,p.2315-2318
Clin Diagn Lab Immunol.,2001年,Vol.8,p.652-657
J Med Virol.,2005年 3月,Vol.76,p.129-136
ウイルス,2002年,Vol.52,p.7-13
J Clin Microbiol.,1993年,Vol.31,p.1630-1634

Hidesaku Yamamoto
Natsuki Morishita

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