Title:
NOVEL ANTAGONIST OF ARGININE VASOPRESSIN ANTIDIURETIC AND/OR BLOOD PRESSURE RAISING ACTIVITY
Document Type and Number:
Japanese Patent JPS5849352
Kind Code:
A
Abstract:
Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or DELTA 3-Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin.
Inventors:
MOURISU MANNINGU
UIRUBAA HENDANON SOUYAA
UIRUBAA HENDANON SOUYAA
Application Number:
JP4478982A
Publication Date:
March 23, 1983
Filing Date:
March 23, 1982
Export Citation:
Assignee:
MEDEIKARU KAREJI OBU OHAIO
UNIV COLUMBIA
UNIV COLUMBIA
International Classes:
A61K38/00; A61K38/095; A61P9/02; A61P43/00; C07K7/16; C07K14/575; (IPC1-7): A61K37/02; A61K37/34; C07C103/52
Other References:
JOURNAL OF MEDICAL CHEMISTRY=1980
JOURNAL OF MEDICAL CHEMISTRY=1978
JOURNAL OF MEDICAL CHEMISTRY=1978
Attorney, Agent or Firm:
Yataro Sasai