Title:
NOVEL COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUND
Document Type and Number:
Japanese Patent JPS62116580
Kind Code:
A
Abstract:
Compounds of formula (I) and pharmaceutically acceptable salts thereof:wherein:X is NH; or O when Ar is of formula (a) and R2 is hydrogen or when Ar is a group of formula (b);R, is hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6alkyl, which phenyl moieties may be substituted by C1-8 alkyl, C1 6 alkoxy or halogen;Ar is a group of formula (a):wherein either R2 is C 1-6 alkoxy and one of R3 R4 and Rs is hydrogen and the other two are selected from hydrogen, halogen, CF3 C1-6 alkoxy, C1-6 alkyl, C1-6-alkylthio, C1-7 acyl, C1-10 carboxylic acylamino, C1-6-alkyl S-(O)n wherein n is 0, 1 or 2, nitro or amino, aminocarbonyl or aminosulphonyl optionally substituted by one or two groups selected from C 1-6 alkyl, C3-8cycloalkyl, C3-8 cycloalkyl C1-4 alkyl or phenyl C1-4alkyl groups any of which phenyl moieties may be substituted by one or two groups selected from halogen, CF3, C1-6 alkyl or C1-6 alkoxy; or R2 is hydrogen and R3 R4 and Rs are independently selected from hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkylthio or halo; or any two on adjacent carbon atoms together are C1-2 alkylenedioxy and the third is hydrogen, C 1-6alkyl, C1-6 alkoxy or halo;or Ar is a group of formual (b);wherein Z is CH2, O, S or NR7 wherein R7 is hydrogen, C1-6 alkyl, C3-7 alkenyl-methyl, phenyl or phenyl C1-4alkyl either of which phenyl moieties may be substituted by one or two of halogen, CF3, C 1-6 alkoxy or C1-6alkyl; and Y is CH or N; or Z is CH or N and Y is NRa or CHRa where Ra is as defined for R7 above;Rb is present when the COX linkage is attached at the phenyl ring, and is selected from hydrogen, halogen, CF3, hydroxy, C1-6 alkoxy or C1-6 alkyl;R6 is hydrogen, halogen, CF3, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-7 acyl, C1-7 acylamino, C1-6 alkylsulphonylamino, N-( C1-6 alkylsulphonyl)-N-C1-4 alkylamino, C1-6 alkylsulphinyl, hydroxy, nitro or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-C1-4alkylamino optionally N-substituted by one or two groups selected from C1-6 alkyl, C3-8 cycloalkyl, C3-8cycloalkyl, C1-4 alkyl, phenyl or phenyl C1-4 alkyl groups or optionally N-disubstituted by C 4-5polymethylene having gastric motility enhancing activity, anti-emetic activity and/or 5-HT M-receptor antagonist activity, a process for their preparation and their use as pharmaceuticals.
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Inventors:
FURANSHISU DEBITSUDO KINGU
Application Number:
JP24728086A
Publication Date:
May 28, 1987
Filing Date:
October 17, 1986
Export Citation:
Assignee:
BEECHAM GROUP PLC
International Classes:
A61K31/435; A61P1/00; A61P1/08; A61P25/04; A61P43/00; C07D453/02; (IPC1-7): A61K31/435; C07D453/02
Attorney, Agent or Firm:
Akizawa Masamitsu