NOVEL FORMULATIONS OF VOLATILE ANESTHETICS AND METHODS OF USE THEREOF FOR REDUCING INFLAMMATION

Japanese Patent JP2017226691

A

PROBLEM TO BE SOLVED: To provide novel formulations of volatile anesthetics and methods of use for treating an inflammation or wound.SOLUTION: In a composition, a component of an emulsion comprising a lipid, such as soybean oil or olive oil, is a solution comprising: an effective amount of a volatile anesthetic, such as isoflurane, halothane, enflurane or sevoflurane, dissolved in an aqueous solution; and a solvent to reduce the volatility, such as dimethyl sulfoxide, N-methyl-2-pyrrolidone, dimethylformamide, dimethylacetamide or ethanol. A method comprises administering the composition via a topical, intrathecal, epidural, transdermal, topical, oral, intra-articular, mucosal, buccal, rectal, vaginal, intramuscular, intravesical or subcutaneous route.SELECTED DRAWING: Figure 1

DANGUOLE SPAKEVICIUS
HATICE OZSOY

JP2017157925A

December 28, 2017

August 18, 2017

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UNIV TEXAS

A61K45/00; A61K9/06; A61K9/08; A61K9/107; A61K9/12; A61K9/127; A61K31/02; A61K31/08; A61K33/00; A61K47/10; A61K47/18; A61K47/20; A61K47/22; A61K47/26; A61K47/44; A61P1/04; A61P9/00; A61P13/08; A61P13/10; A61P17/02; A61P19/02; A61P19/04; A61P21/00; A61P23/02; A61P27/02; A61P29/00; A61P35/00

AM. J. PHYSIOL. RENAL. PHYSIOL., vol. 291, JPN6014020924, 2006, pages 67 - 78, ISSN: 0004213398
ANESTHESIA & ANALGESIA, vol. 106, no. 2, JPN6014020925, 2008, pages 371 - 378, ISSN: 0004213399

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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