NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

Title:

NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

Document Type and Number:

Japanese Patent JP2022084699

Kind Code:

A

Abstract:

To provide: novel monocyclic and bicyclic ring system substituted carbanucleoside analogues useful as PRMT5 inhibitors; and pharmaceutical compositions comprising the compounds as an active ingredient.SOLUTION: The invention provides compounds represented by the formula in the figure.SELECTED DRAWING: None

More Like This:

JP6936236	Use of therapeutic compounds, compositions and methods thereof
JP2534401	INDUSTRIAL APPLICABILITY: N- and O-substituted aminophenol derivatives, intermediates for producing the same, and their use.

Inventors:

WU TONGFEI
DIRK BREHMER
LIJS BEKE
AN BOECKX
GASTON STANISLAS MARCELLA DIELS
EDWARD CHARLES LAWSON
LIEVEN MEERPOEL
VINEET PANDE
MARCUS CORNELIS BERNARDUS CATHARINA PARADE
WIM BERT GRIET SCHEPENS
SUN WEIMEI
JOHANNES WILHELMUS JOHN F THURING
MARCEL VIELLEVOYE

Application Number:

JP2022033419A

Publication Date:

June 07, 2022

Filing Date:

March 04, 2022

Export Citation:

Click for automatic bibliography generation Help

Assignee:

JANSSEN PHARMACEUTICA NV

International Classes:

C07D487/04; A61K31/519; A61K31/5383; A61P1/18; A61P3/00; A61P7/00; A61P7/02; A61P9/00; A61P11/00; A61P13/12; A61P15/08; A61P25/28; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07D519/00

Attorney, Agent or Firm:

Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori

Previous Patent: Vehicular communication system

Next Patent: Automatic and manual methods for the isolation of extracellular vesicles from biological fluids and ...