酵素SOAT-1の阻害剤である新規フェニル尿素誘導体、ならびにこれらを含む医薬および化粧用組成物

Title:

酵素SOAT-1の阻害剤である新規フェニル尿素誘導体、ならびにこれらを含む医薬および化粧用組成物

Document Type and Number:

Japanese Patent JP2010538044

Kind Code:

A

Abstract:

Phenylurea compounds of formula (I): are inhibitors of the enzyme SOAT-1. Cosmetic and pharmaceutical compositions containing them are useful for treating various disorders, such as acne, or have cosmetic applications. An exemplary species is 1-[1-(biphenyl-2-ylamino)cyclopentylmethyl]-3-(2,6-diisopropylpheny)urea.

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WO/1995/026328	BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS

Inventors:

Tibor portal

Application Number:

JP2010523510A

Publication Date:

December 09, 2010

Filing Date:

September 05, 2008

Export Citation:

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Assignee:

Galderma Research and Development

International Classes:

C07C275/28; A61K8/42; A61K8/49; A61K9/06; A61K31/17; A61K31/351; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4468; A61P3/06; A61P9/10; A61P17/04; A61P17/08; A61P25/28; A61P27/02; A61P43/00; A61Q5/00; A61Q19/00; A61Q19/10; C07C273/18; C07D211/58; C07D211/96; C07D213/38; C07D309/14; C07B61/00

Domestic Patent References:

JPH03246257A

1991-11-01

Foreign References:

WO1998054153A1

1998-12-03

Other References:

JPN6013034002; Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．３７，　Ｎｏ．１２, 1994, ｐ．１８１０-１８２２
JPN6013034005; Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．３６，　Ｎｏ．２２, 1993, ｐ．３３００-３３０７

Attorney, Agent or Firm:

Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro

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