NOVEL PLATELET-AGGLUTINATION SUPPRESSING SUBSTANCE AGLYCERIDE A, B AND C, PRODUCTION AND USE THEREOF

Title:

NOVEL PLATELET-AGGLUTINATION SUPPRESSING SUBSTANCE AGLYCERIDE A, B AND C, PRODUCTION AND USE THEREOF

Document Type and Number:

Japanese Patent JPS62190193

Kind Code:

A

Abstract:

NEW MATERIAL:A platelet-agglutination suppressing substance aglyceride A having the following physicochemical properties; Molecular formula; C18H36O4 (by, high-resolution massspectroscopy). Molecular weight; 316 (by GC-MS spectroscopy), [α]D21=+9.7° (C=0.03, CHCl3). Soluble in acetone, methanol, ethanol, ethyl ethyl acetate, chloroform and benzene and insoluble in water. Neutral fat-soluble monoglyceride. Colorless; etc.

USE: A hypotensor and remedy for thrombosis.

PREPARATION: A microorganism, belonging to the genus streptomyces and capable of producing a platelet-agglutination suppressing substance aglyceride A, B or C [preferably streptomyces spiecies OM-3209 (FERM P-8427)] is cultured at around 27°C and acidic W neutral pH for 1W8 days by submerged aeration cultivation.

Inventors:

OMURA SATOSHI
NAKAGAWA AKIRA

Application Number:

JP3238686A

Publication Date:

August 20, 1987

Filing Date:

February 17, 1986

Export Citation:

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Assignee:

KITASATO INST

International Classes:

C07G99/00; A61K35/74; A61K38/00; A61P7/02; C07C69/30; C12P1/06; C12R1/465; (IPC1-7): A61K35/74; A61K37/22; C07C69/30; C07G17/00; C12P1/06; C12R1/465

Attorney, Agent or Firm:

Kazunori Kobayashi

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