Title:
NOVEL RUTHENIUM COMPLEX HAVING AMINO ACID AS LIGAND AND ASYMMETRIC HYDROGENATION USING THE SAME
Document Type and Number:
Japanese Patent JP3494549
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject novel transition metal complex that comprises a specific ruthenium complex having amino acids as ligands and can be inexpensively and industrially utilized as a catalyst for hydrogen-transferring type reduction reaction as asymmetric hydrogenation reaction.
SOLUTION: This compound is a novel amino acid-ruthenium complex and represented by formula I (R1 is H, a lower alkyl, methanesulfonyl, p- toluenesulfonyl, trifluoromethanesulfonyl, camphorsulfonyl, acyl, venzoyl; R2 is a lower alkyl; phenyl, benzyl, an aryl; R1 and R2 incorporate to form a heterocyclic ring; R3 and R8 are each H, a lower alkyl, a lower alkoxycarbonyl; X is a halogen) and is used as a catalyst for a hydrogen-transferring type reduction reaction to reduce an aromatic ketone of formula II [Ar is a (substituted) phenyl, (substituted) naphthyl] to convert to an optically active aromatic alcohol represented by formula III. This compound is prepared by reaction of L-(-)- proline with tetrachlorobis(p-cymene) diruthenium in a solvent.
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Inventors:
Tetsuo Ohta
Isao Furukawa
Noboru Sayo
Isao Furukawa
Noboru Sayo
Application Number:
JP7281497A
Publication Date:
February 09, 2004
Filing Date:
March 11, 1997
Export Citation:
Assignee:
Takasago International Corporation
International Classes:
B01J31/22; C07B61/00; C07C29/38; C07C33/05; C07C33/20; C07F15/00; (IPC1-7): C07C29/38; B01J31/22; C07C33/20
Other References:
【文献】Journal of Organometallic Chemistry,(1990), Vol.396,p.C17-C21
【文献】Journal of Organometallic Chemistry,(1977), Vol.127,p.C55-C58
【文献】Journal of Organometallic Chemistry,(1977), Vol.127,p.C55-C58
Attorney, Agent or Firm:
Nobuo Ono