Title:
NOVEL SECONDARY BILE ACID-DECREASING AGENT
Document Type and Number:
Japanese Patent JP2011184311
Kind Code:
A
Abstract:
To provide a novel secondary bile acid-decreasing agent, more particularly a novel agent decreasing a dehydroxylation product of the 7-position hydroxy group among secondary bile acids formed by reductive metabolism of a primary bile acid.
The agent decreasing a dehydroxylation product of the 7-position hydroxy group among secondary bile acids formed by reductive metabolism of a primary bile acid includes an electron acceptor as an effective ingredient. The agent directly intervenes in bile acid metabolism of an enterobacterium to more effectively inhibit formation of a secondary bile acid exhibiting intestinal carcinogenicity thereby to decrease a carcinogenic secondary bile acid compared with conventional ones exhibiting indirect actions.
Inventors:
YOKOTA ATSUSHI
ISHIZUKA SATOSHI
FUKITANI SATOSHI
ISHIZUKA SATOSHI
FUKITANI SATOSHI
Application Number:
JP2010048241A
Publication Date:
September 22, 2011
Filing Date:
March 04, 2010
Export Citation:
Assignee:
UNIV HOKKAIDO
International Classes:
A61K45/00; A61K31/194; A61P1/04; A61P3/06; A61P29/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Shingo Sagawa
Motoko Kobayashi
Kiyotaka Kanamaru
Motoko Kobayashi
Kiyotaka Kanamaru