Title:
NOVEL SULFINAMIDE DERIVATIVE, ITS PRODUCTION AND MEDICINE CONTAINING THE SAME
Document Type and Number:
Japanese Patent JP3307966
Kind Code:
B2
Abstract:
PURPOSE: To provide a new sulfonamide deriv. which strongly suppresses the biological activity of TXA2 and is used for the treatment and prevention of ischemia, cerebrovascular diseases, peripheral vascular diseases and lipid imbalance, allergic diseases and inflammations.
CONSTITUTION: The compd. of formula I [R1 is an aryl, heterocyclic group; one of R2, R3 is W and the other is H, a halogen, CF3, alkyl cycloalkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonylacyl, thioacylhydroxyl, NH2, NO2, CN, azide, aryl; R4 to R7 are R2, R3 exclusive of W; W is Z-Ar-(CH2)q-A (A is CO2H, SO3H, etc.; (q) is 0 to 4; Ar is an aryl, arom. heterocyclic group; Z is O, CH2, coupler); Y is (CH2)3-B-(CH2)t ((s), (t) are 0 to 2; B is O, S, N, CO, CS, etc.); (n) is 0, 1]; for example, trans-4-[(2-[[(4-chlorophenyl)sulfonyl]-amino]cyclopentyl) methyl]benzeneacetic acid. The compd. is obtd. by the reaction of the compds. of formula II and terminal III.
Inventors:
Lalday Claude
Gerrier daniel
Syavernatsk Gilet
Colonges Francois
Gerrier daniel
Syavernatsk Gilet
Colonges Francois
Application Number:
JP27900291A
Publication Date:
July 29, 2002
Filing Date:
July 31, 1991
Export Citation:
Assignee:
Lifter
International Classes:
A61K31/195; A61K31/215; A61K31/34; A61K31/341; A61K31/35; A61K31/351; A61K31/396; A61K31/397; A61K31/415; A61K31/47; A61K31/66; A61K31/665; A61K31/675; A61P7/02; A61P9/08; A61P9/10; A61P11/08; A61P43/00; C07C211/17; C07C211/35; C07C215/38; C07C217/52; C07C229/34; C07C255/46; C07C303/36; C07C303/38; C07C311/16; C07C311/17; C07C311/19; A61K31/18; C07C311/20; C07C311/29; C07C317/14; C07C323/67; C07D203/26; C07D205/04; C07D215/36; C07D233/54; C07D233/84; C07D237/04; C07D257/04; C07D307/14; C07D307/64; C07D309/04; C07D333/34; C07F9/38; (IPC1-7): C07C311/17; A61K31/18; A61K31/195; A61K31/215; A61K31/34; A61K31/35; A61K31/415; A61K31/47; A61K31/66; A61K31/665; A61K31/675; C07C215/38; C07C217/52; C07C229/34; C07C255/46; C07C303/36; C07C303/38; C07C311/19; C07C311/20; C07D203/26; C07D205/04; C07D233/84; C07D307/14; C07D309/04
Attorney, Agent or Firm:
Shigeru Yagita (2 outside)