Title:
NUCLEIC ACID MOLECULE INHIBITING TARGET GENE EXPRESSION
Document Type and Number:
Japanese Patent JP2023127512
Kind Code:
A
Abstract:
To provide a novel nucleic acid molecule for inhibiting target gene expression, (1) having gene expression inhibitory activity equivalent to or greater than siRNA, (2) having no off-target effect caused by a sense strand, and (3) enabling the design of a wider range of antisense strand sequences (expansion of targetable sequence range) without being restricted by the above strand bias rules.SOLUTION: Provided is a nucleic acid molecule represented by the general formula below [where, the definition of each symbol is as described in the specification].SELECTED DRAWING: None
Inventors:
SHIBATA ATSUSHI
EMURA CHISATO
SHIRAMIZU HISAO
IWAKAMI YUSUKE
AOKI ERIKO
EMURA CHISATO
SHIRAMIZU HISAO
IWAKAMI YUSUKE
AOKI ERIKO
Application Number:
JP2022031347A
Publication Date:
September 13, 2023
Filing Date:
March 01, 2022
Export Citation:
Assignee:
BONAC CORP
International Classes:
C12N15/11; A61K31/7105; A61K31/711; A61K48/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Hajime Takashima
Mitsuyoshi Kamada
Kyoko Doi
Yaeko Tamura
Hirofumi Taima
Atsuko Akai
Tomiya Tosaki
Mitsuyoshi Kamada
Kyoko Doi
Yaeko Tamura
Hirofumi Taima
Atsuko Akai
Tomiya Tosaki