ペメトレキセドを含む経口用医薬組成物及びその製造方法

Japanese Patent JP7079030

B2

The present invention relates to an oral pharmaceutical composition containing pemetrexed as a water-soluble anticancer drug and a method of manufacturing the same, and more particularly to an oral pharmaceutical composition, in which an ion-binding complex of pemetrexed and a bile acid derivative as an oral absorption enhancer is formed, mixed with a pharmaceutical additive, and then provided in the form of a capsule or a tablet through pressing or included in the internal water phase of a w/o/w (water-in-oil-in-water) multiple nanoemulsion, thus increasing the oral bioavailability of pemetrexed as the water-soluble anticancer drug, whereby pemetrexed, which is currently administered only in the form of an injection formulation, can be manufactured into a formulation capable of being orally administered, ultimately alleviating inconvenience and problems with use of injection formulations, improving patient compliance and contributing to a reduction in medical expenses.

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Park, Jin Woo
Byung, Yongro
Choi, Young Kwon
Chan, Kang Young
Lee, Jebom

JP2020545022A

June 01, 2022

October 10, 2018

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I Cure BNP Company Limited

A61K31/519; A61K9/10; A61K9/107; A61K9/113; A61K31/121; A61K31/353; A61K31/513; A61K36/185; A61K47/10; A61K47/12; A61K47/14; A61K47/28; A61K47/40; A61K47/44; A61P35/00; A61P43/00

JP2008500387A

US20080026077

Eur. J. Pharm. Sci.,2016年,Vol.82,pp.1-10
J. Pharm. Sci.,Vol.102 No.2,2013年,pp.341-346
European Journal of Pharmaceutical Sciences,2016, Vol.82,pp.1-10
Journal of Pharmaceutical Sciences,2013, Vol.102, No.2,pp.341-346

Asahina Patent Office

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