Title:
PDX1 revelation Sexual endoderm
Document Type and Number:
Japanese Patent JP6265942
Kind Code:
B2
Abstract:
Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
Inventors:
Damour Kevin Allen
Agrnick Arandy
Area saar susan
Betzge Emmanuel E
Agrnick Arandy
Area saar susan
Betzge Emmanuel E
Application Number:
JP2015111656A
Publication Date:
January 24, 2018
Filing Date:
June 01, 2015
Export Citation:
Assignee:
Viasight, Inc.
International Classes:
C07K14/71; C12N5/071; C12N5/00; C12N5/073; C12N5/0735
Domestic Patent References:
| JP9188630A | ||||
| JP2004502425A | ||||
| JP2002538779A |
Foreign References:
| WO2003062405A1 | ||||
| WO2002092756A1 | ||||
| WO2002096203A1 | ||||
| WO2003050249A1 |
Other References:
Science (2001) Vol.292, pp.1389-1394
Diabetes (2005) Vol.54, No.2, pp.301-305
Biochem. J. (2004) Vol.379, pp.749-756
Mechanism of Development (2003) Vol.120, pp.45-57
Molecular and Cellular Biology (2000) Vol.20, No.12, pp.4445-4454
Proc. Natl. Acad. Sci. USA. (2000) Vol.97, No.21, pp.11307-11312
Diabetes (2005) Vol.54, No.2, pp.301-305
Biochem. J. (2004) Vol.379, pp.749-756
Mechanism of Development (2003) Vol.120, pp.45-57
Molecular and Cellular Biology (2000) Vol.20, No.12, pp.4445-4454
Proc. Natl. Acad. Sci. USA. (2000) Vol.97, No.21, pp.11307-11312
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi