Title:
PALATABLE COMPOSITIONS INCLUDING SODIUM PHENYLBUTYRATE AND USES THEREOF
Document Type and Number:
Japanese Patent JP2022106927
Kind Code:
A
Abstract:
To provide palatable pharmaceutical compositions including sodium phenylbutyrate.SOLUTION: The present invention discloses a pharmaceutical composition for oral administration of sodium phenylbutyrate, comprising 15-65% by total weight of the sodium phenylbutyrate and 5-50% by total weight of a taste-mask coating comprising a polymer formed from dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate. The present invention further discloses methods for treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.SELECTED DRAWING: None
Inventors:
LEAH E APPEL
JOSHUA R SHOCKEY
D CHRISTOPHER SCHELLING
JOSHUA R SHOCKEY
D CHRISTOPHER SCHELLING
Application Number:
JP2022076939A
Publication Date:
July 20, 2022
Filing Date:
May 09, 2022
Export Citation:
Assignee:
ACER THERAPEUTICS INC
International Classes:
A61K31/192; A61K9/14; A61K47/04; A61K47/10; A61K47/32; A61K47/36; A61K47/38; A61P3/00; A61P21/00; A61P25/00; A61P25/16
Domestic Patent References:
| JP2010083886A | 2010-04-15 | |||
| JP2014517057A | 2014-07-17 | |||
| JP2014521713A | 2014-08-28 | |||
| JP2016006025A | 2016-01-14 | |||
| JP2014516961A | 2014-07-17 | |||
| JP2015533164A | 2015-11-19 | |||
| JP2007525413A | 2007-09-06 | |||
| JP2007532623A | 2007-11-15 |
Foreign References:
| FR2959129A1 | 2011-10-28 | |||
| WO2011011781A1 | 2011-01-27 | |||
| EP2599477A1 | 2013-06-05 | |||
| EP2389932A1 | 2011-11-30 | |||
| US20040152784A1 | 2004-08-05 | |||
| WO2008148798A2 | 2008-12-11 |
Other References:
ARCHIVES OF DISEASE IN CHILDHOOD, vol. 97, JPN6023015048, 2012, pages 1081 - 1085, ISSN: 0005037527
PEDIATR DRUGS, vol. 16, JPN6023015049, 2014, pages 407 - 415, ISSN: 0005037528
PLOS ONE, vol. 9, no. 11, JPN6023015047, 2014, pages 110086, ISSN: 0005037529
PEDIATR DRUGS, vol. 16, JPN6023015049, 2014, pages 407 - 415, ISSN: 0005037528
PLOS ONE, vol. 9, no. 11, JPN6023015047, 2014, pages 110086, ISSN: 0005037529
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto