Title:
PERTUSSIS VACCINE
Document Type and Number:
Japanese Patent JP3892165
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a pertussis vaccine that causes no coagulation of antigen protein on the inactivation, and is safe to human body and stable by admixing catechins as an inactivating agent for pertussis physiologically active substances.
SOLUTION: This vaccine includes a catechin as an inactivating agent for pertussis physiologically active substances. In a preferred embodiment, the catechin is obtained by extracting it from raw tea leaves, green tea, oolong tea or black tea with water, hot water, a variety of alcohols or ethyl acetate, and separating and purifying the extract. In the vaccine, the concentration of the catechin is adjusted to 0.01-10 mM. The objective pertussis vaccine is prepared by mixing the pertussis physiologically active substances with the catechin to effect the inactivation reaction, dialyzing the reaction mixture to remove the catechin and obtain pertussis toxoid and allowing the pertussis toxoid to adsorb to the adjuvant. An new vaccine having excellent pertussis immune effect can be provided thereby.
Inventors:
Chuo Takeo
Masahiko Endo
Mineo Watanabe
Masahiko Endo
Mineo Watanabe
Application Number:
JP4880699A
Publication Date:
March 14, 2007
Filing Date:
February 25, 1999
Export Citation:
Assignee:
ITO EN Co., Ltd.
International Classes:
A61K39/10; C12N1/20; A61K31/353; A61K47/22; (IPC1-7): A61K39/10; A61K47/22; C12N1/20
Domestic Patent References:
| JP55118420A | ||||
| JP53109912A |
Other References:
堀内義信、他4名,「茶およびカテキンの百日咳菌に対する防御作用」,感染症学雑誌,1992年 5月,第66巻,第5号,p.599-605
Attorney, Agent or Firm:
Saburo Takeuchi
Michio Ichizawa
Kiyoshi Hashimoto
Michio Ichizawa
Kiyoshi Hashimoto
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