Title:
PHARMACEUTICAL COMPOSITION HAVING ANALGESIC EFFECT
Document Type and Number:
Japanese Patent JP3784843
Kind Code:
B2
Abstract:
PURPOSE: To provide the composition which contains a specified ratio of naproxen and arginine and an aq. solution of which has a pH value within a specified range and also, which is capable of rapidly showing an analgesic effect and further, excellent in pharmaceutical-effect durability and properties with respect to granulation and compression molding.
CONSTITUTION: This composition contains (A) naproxen and (B) arginine such as L-arginine in a molar ratio of (the component A)/(the component B) of 1/0.8 to 1/1.5 and further optionally contains (C) a pharmaceutically-acceptable basic substance other than arginine, such as sodium hydrogencarbonate, in a molar ratio of the substance to the component A of ≤0.7. Also, an aq. solution of the composition has a pH value of 7.5 to 9.0. The naproxen content in the composition is preferably 125, 250 or 500 mg.
Inventors:
Federico Stropolo
Danielle Bonadeo
Luigi Bigano
Annivale Gatherniga
Danielle Bonadeo
Luigi Bigano
Annivale Gatherniga
Application Number:
JP5571694A
Publication Date:
June 14, 2006
Filing Date:
March 25, 1994
Export Citation:
Assignee:
ZAMBON GROUP S.p.A.
International Classes:
A61K31/192; A61K9/00; A61K9/16; A61K9/46; A61K31/19; A61K31/195; A61K31/198; A61K31/205; A61K47/02; A61K47/18; A61P25/04; (IPC1-7): A61K31/19; A61K31/195
Domestic Patent References:
| JP63041420A |
Foreign References:
| EP0486045A1 |
Attorney, Agent or Firm:
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba
Toshio Takano
Toshio Nakajima
Hiromi Matoba