Title:
PHARMACEUTICAL PREPARATION AND METHOD OF TREATMENT OF HUMAN MALIGNANCY WITH ARGININE DEPRIVATION
Document Type and Number:
Japanese Patent JP2013172743
Kind Code:
A
Abstract:
To provide an isolated recombinant human arginase I having a purity of 80-100%, and to provide fed-batch fermentation operation for production of isolated and purified recombinant human arginase.
The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain adequate arginine depletion in a patient. The present invention also provides a pharmaceutical composition comprising the modified enzyme and method for treatment of diseases using the pharmaceutical composition.
Inventors:
CHENG NING MAN
LEUNG YUN CHUNG
LO WAI HUNG
LEUNG YUN CHUNG
LO WAI HUNG
Application Number:
JP2013101584A
Publication Date:
September 05, 2013
Filing Date:
May 13, 2013
Export Citation:
Assignee:
BIO CANCER TREAT INTERNATL LTD
International Classes:
C12N9/14; C12N15/09; A61K9/08; A61K38/00; A61K38/44; A61K38/46; A61P1/00; A61P35/00; C07H21/04; C12N1/21; C12N9/06; C12N9/78; C12N9/80; C12N9/96; C12N15/55; C12N15/74; C12P21/06; C12R1/125
Foreign References:
| WO1998024473A1 | 1998-06-11 |
Other References:
JPN6012020175; ＰＮＡＳ，Ｖｏｌ．８４（１９８７）ｐ．４１２-４１５
JPN5005001237; ＳＡＶＯＣＡ Ｋ Ｖ: ＣＡＮＣＥＲ ＢＩＯＣＨＥＭＩＳＴＲＹ ＢＩＯＰＨＹＳＩＣＳ Ｖ７ Ｎ３, 1994, Ｐ２６１-２６８, ＧＯＲＤＯＮ ＡＮＤ ＢＲＥＡＣＨ ＳＣＩＥＮＣＥ ＰＵＢＬＩＳＨＥＲ， ＩＮＣ
JPN5005001237; ＳＡＶＯＣＡ Ｋ Ｖ: ＣＡＮＣＥＲ ＢＩＯＣＨＥＭＩＳＴＲＹ ＢＩＯＰＨＹＳＩＣＳ Ｖ７ Ｎ３, 1994, Ｐ２６１-２６８, ＧＯＲＤＯＮ ＡＮＤ ＢＲＥＡＣＨ ＳＣＩＥＮＣＥ ＰＵＢＬＩＳＨＥＲ， ＩＮＣ
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Shinichiro Yamanaka
Hiroshi Yamazaki
Kenji Tomita
Shinichiro Yamanaka
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