シネオールとアモキシシリンとを含む医薬製剤

Japanese Patent JP7033586

B2

The present invention relates to a pharmaceutical formulation in powder form comprising amoxicillin, cineole and a pharmaceutically acceptable oil. The present formulation may also comprise clavulanic acid. It is intended for oral administration, preferably after suspension in an aqueous solvent. The present invention also relates to a combination of cineole and amoxicillin for use in the treatment of an infectious pathology, preferably a bacterial infection, in an individual. The present combination may also comprise a β-lactamase inhibitor, preferably clavulanic acid. The combination according to the invention makes it possible in particular to combat infections caused by bacteria that are resistant to antibiotics, preferably to antibiotics of the β-lactamine family.

Le Mar Adnanu
Akmook Ahmed Amine

JP2019515760A

March 10, 2022

June 02, 2017

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ADVANCED SCIENTIFIC DEVELOPEMENTS

A61K31/43; A61K9/16; A61K31/352; A61K31/424; A61K47/44; A61P1/02; A61P11/00; A61P13/10; A61P13/12; A61P15/00; A61P19/02; A61P19/08; A61P27/16; A61P31/04; A61P43/00

JP2014507441A

WO2016041958A1

Adina Catinca Gradinaru et al,Interactions between cardamom essential oil and conventional antibiotics against Staphylococcus Aureus clinical isolates,Farmacia,2014年,vol 62, no 6,1214-1222
Hanan. H. Abd El-Kalek et al,SYNERGISTIC EFFECT OF CERTAIN MEDICINAL PLANTS AND AMOXICILLIN AGAINST SOME CLINICAL ISOLATES OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS CLINICAL ISOLATES,International Journal of Pharmaceutical Applications,2012年,vol 3, no 3,387-398

Katsumi Iseki
Shuhei Kaneko
Wataru Onishi

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