Title:
PHENYLCARBOXYLIC DERIVATIVE
Document Type and Number:
Japanese Patent JP3694774
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a novel compound that has the action of inhibiting simultaneously fatty acid biosynthesis and cholesterol biosynthesis, can simultaneously lower both levels of triglyceride and cholesterol in blood with high safety and is useful for treatment of hyperlipemia.
SOLUTION: This compound is a phenylcarboxylic acid derivative represented by formula I [A is a lower alkyl or the like; Q is formula II (R3 and R4 are each H or the like); B is O or the like; R1 is H or the like; R2 is H or the like; n is 1 or 2; m is 0 or 1] or its salt, typically 1-(4-chlorophenyl)-5- methyl-4-(4'-ethoxycarbonylphenoxy)methylpyrazole. The compound of formula I is prepared, for example, by reducing a compound of the formula: A- Q-(CH2)n-1-CO2C2H5, for example, 1-(4-chlorophenyl)-5-methyl-4- ethoxycarbonylpyrazole, chlorinating the product and allowing the chlorinated product to react with a compound of formula III, preferably at about 0-50°C for 1-12 hours.
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Inventors:
Makoto Kitade
Ohno Tomoyasu
Tadashi Terada
Takuya Asao
Akira Yamamoto
Haruo Yamada
Hidekazu Miyake
Ohno Tomoyasu
Tadashi Terada
Takuya Asao
Akira Yamamoto
Haruo Yamada
Hidekazu Miyake
Application Number:
JP30038497A
Publication Date:
September 14, 2005
Filing Date:
October 31, 1997
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
C07D249/08; A61K31/41; A61K31/415; A61K31/425; A61K31/426; A61K31/44; A61K31/4427; A61P3/06; A61P9/10; A61P43/00; C07D231/12; C07D233/60; C07D277/24; C07D401/04; C07D403/04; C07D417/04; (IPC1-7): C07D231/12; A61K31/41; A61K31/415; A61K31/425; A61K31/44; A61P3/06; A61P9/10; C07D233/60; C07D249/08; C07D277/24; C07D401/04; C07D403/04; C07D417/04
Domestic Patent References:
| JP3275666A |
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Takeshi Ohara
Hiroji Nakagawa
Yasumitsu Tate
Kenji Saito
Jun Fujii
Hitoshi Seki
Mutsuko Nakano
Shinsuke Otsuki
Suzuki Katsuto
Kakehi Yuro
Takeshi Ohara
Hiroji Nakagawa
Yasumitsu Tate
Kenji Saito
Jun Fujii
Hitoshi Seki
Mutsuko Nakano
Shinsuke Otsuki
Suzuki Katsuto