Title:
POLYETHYLENE GLYCOL DERIVATIVE, MODIFIED PEPTIDE AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JP2997004
Kind Code:
B2
Abstract:
A polyethylene glycol derivative of the formula wherein R1 and R2 are the same or different and each represents a lower alkyl and m and n are same or different and each represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by said polyethylene glycol derivative and a method for production thereof are described. The polyethylene glycol derivative (I) is capable of modifying the guanidino groups in peptides. The thereby modified peptides are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.
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Inventors:
IKEDA ZENJI
MAEDA HIROO
KAI HIROYUKI
ONO KEIICHI
MAEDA HIROO
KAI HIROYUKI
ONO KEIICHI
Application Number:
JP9063790A
Publication Date:
January 11, 2000
Filing Date:
April 04, 1990
Export Citation:
Assignee:
SUMITOMO PHARMA
International Classes:
C12N9/00; A61K38/00; A61K47/48; C07K1/107; C07K1/113; C07K14/00; C07K14/575; C07K14/65; C08G65/28; C08G65/32; C08G65/329; C08G65/331; C08G65/334; C12N9/96; (IPC1-7): C08G65/28; C07K1/00; C07K14/47; C08G65/329; C12N9/00
Other References:
Ｋ．Ｔａｋａｈａｓｈｉ，「Ｔｈｅ ｒｅａｃｔｉｏｎ ｏｆ ｐｈｅｙｌ ｇｌｙｏｘａｌ ｗｉｔｈ ａｒｇｉｎｉｎｅ ｒｅｓｉｄｕｅｓ ｉｎ Ｐｒｏｔａｉｎｓ」，Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｗｉｓｔｒｙ，２４３巻，２８号，ｐ．６１７１−６１７９（１９６８）
Ｔ．Ｙｏｓｈｉｍｏｔｏ ｅｔ ａｌ．，「Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ Ｐｏｌｙｅｔｈｙｌｅｖｅ ｇｌｙｃｏｌ−ｗｏｄｉｆｉｅｄ Ｌ−ａｓｐａｒａｇｉｎａｓｅ ｆｒｏｍ ｅｓｃｈｅｒｉｃｈｉａ ｃｏｌｉ ａｎｄ ｉｔｓ ａｐｐｌｉｃａｔｉｏｎ ｔｏ ｔｈｅｒａｐｙ ｏｆ ｌｅｕｋｅｍｉａ」，Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｃａｕｃｅｒ Ｒｅｓｅｒｃｈ ，７７巻，１２号 ，ｐ．１２６４−１２７０（１９８６）
Ｔ．Ｙｏｓｈｉｍｏｔｏ ｅｔ ａｌ．，「Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ Ｐｏｌｙｅｔｈｙｌｅｖｅ ｇｌｙｃｏｌ−ｗｏｄｉｆｉｅｄ Ｌ−ａｓｐａｒａｇｉｎａｓｅ ｆｒｏｍ ｅｓｃｈｅｒｉｃｈｉａ ｃｏｌｉ ａｎｄ ｉｔｓ ａｐｐｌｉｃａｔｉｏｎ ｔｏ ｔｈｅｒａｐｙ ｏｆ ｌｅｕｋｅｍｉａ」，Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｃａｕｃｅｒ Ｒｅｓｅｒｃｈ ，７７巻，１２号 ，ｐ．１２６４−１２７０（１９８６）
Attorney, Agent or Firm:
Toshio Nakamura