Title:
標的真核細胞のサイトゾルへのポリペプチドカーゴの形質導入効率を改善するためのポリペプチドベースのシャトル剤、その使用、それと関連する方法及びキット
Document Type and Number:
Japanese Patent JP6956705
Kind Code:
B2
Abstract:
The present description relates to synthetic peptides useful for increasing the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells. More specifically, the present description relates to synthetic peptides and polypeptide-based shuttle agents comprising an endosome leakage domain (ELD) operably linked to a cell penetrating domain (CPD), or an ELD operably linked to a histidine-rich domain and a CPD. Compositions, kits, methods and uses relating to same are also described.
Inventors:
David Guay
Thomas Del Judith
Jean-Pascal Lepetit-Stoufaes
Thomas Del Judith
Jean-Pascal Lepetit-Stoufaes
Application Number:
JP2018503698A
Publication Date:
November 02, 2021
Filing Date:
April 08, 2016
Export Citation:
Assignee:
Feldan Bio Inc.
International Classes:
C07K19/00; A61K48/00; A61P43/00; C07K7/08; C07K14/00; C12N5/10; C12N15/09
Other References:
Journal of Controlled Release (2012) Vol.163, pp.293-303
Biomaterials (2008) Vol.29, pp.2408-2414
Peptides (2012) Vol.37, pp.273-284
PLOS ONE (2013) Vol.8, No.7, e70108, pp.1-11
Biomaterials (2008) Vol.29, pp.2408-2414
Peptides (2012) Vol.37, pp.273-284
PLOS ONE (2013) Vol.8, No.7, e70108, pp.1-11
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe
Previous Patent: Pachinko machine
Next Patent: Substrate with metal nanowire layer formed and its manufacturing method
Next Patent: Substrate with metal nanowire layer formed and its manufacturing method