Title:
PRACTICAL METHOD FOR REDUCING AMIDE AND LACTAM
Document Type and Number:
Japanese Patent JP2010168357
Kind Code:
A
Abstract:
To provide a practical method for reducing amides and lactams.
Amides or lactams can be reduced respectively into alcohols or amino alcohols in the presence of a group 8(VIII) transition metal complex, a base and hydrogen gas (H2). By appropriately combining the group 8(VIII) transition metal complex, the base, a reaction solvent, hydrogen gas pressure and reaction temperature, a highly practical reduction method can be provided. The method is a practical method for reducing amides and lactams, applicable to a broad scope of substrates because of being usable as a substitute for the existing method to use a stoichiometric hydride reducing agent and ensuring achievement of desired reduction under relatively mild reaction conditions.
Inventors:
IKARIYA TAKAO
ITO MASATO
OTSUKA TAKASHI
ITO MASATO
OTSUKA TAKASHI
Application Number:
JP2009285820A
Publication Date:
August 05, 2010
Filing Date:
December 17, 2009
Export Citation:
Assignee:
TOKYO INST TECH
CENTRAL GLASS CO LTD
CENTRAL GLASS CO LTD
International Classes:
C07C29/149; C07C33/20; C07C33/22; C07C33/46; C07C215/16; C07C269/06; C07C271/16; C07C303/40; C07C311/04; C07C311/17; C07C311/29; C07B61/00
Attorney, Agent or Firm:
Makoto Koide