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Title:
PREPARATION OF 2-(3-BENZOYLPHENYL)-PROPIONIC ACID AND ITS INTERMEDIATE
Document Type and Number:
Japanese Patent JPS5536450
Kind Code:
A
Abstract:

PURPOSE: To obtain the title compound useful as an antiplogistic and analgesic in high yield, by hydrolyzing a condenszate of easily available 3-benzyl acetophenone with an α-halogeno-acetate, by decarboxylating the hydrohyzate, and by oxidizing the resulting product with a strong oxidizing agent.

CONSTITUTION: 3-Benzylacetophenone is condensed with an α-halogenoacetate under the conditions of Darzen's condensation to give a glycidate of formula I: (-COOR is esterified carboxyl group), which is hydrolyzed in the presence of an alkali, and decarboxylated in the presence of a strong acid, e.g. HCl, to form novel 2-(3-benzylphenyl)-propionaldehyde of formula II. The methylene and aldehyde groups of the aldehyde are oxidized with a strong oxidizing agent, e.g. a permanganate, to afford 2-(3-benzoylphenyl)-propionic acid of formula III.


Inventors:
UEYAMA TAMIO
HORIUCHI SUEO
Application Number:
JP11046778A
Publication Date:
March 14, 1980
Filing Date:
September 07, 1978
Export Citation:
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Assignee:
HAMARI YAKUHIN KOGYO KK
International Classes:
C07C59/84; C07C47/23; C07C51/00; C07C51/16; C07C67/00; (IPC1-7): C07C47/23; C07C51/16; C07C59/84
Domestic Patent References:
JPS5165730A1976-06-07
JPS5116636A1976-02-10
JPS477024A



 
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