PURPOSE: To obtain the titled compound useful as an intermediate for a 3- cephem compound having antibacterial activity in high purity in high yield, by reducing a cephemcarboxylic acid derivative having thiomethyl at 3-position with a combination of a metal and an ammonium salt of an acid.
CONSTITUTION: A cephemcarboxylic acid derivative shown by the formula I [R1 is (protected)amino; R2 is (protected)carboxy; R3 is halogen, (substituted)heterocyclic thio] having thiomethyl at 3-position is reduced with a combination of a metal (e.g., zine, etc.) and an ammonium salt (e.g., ammonium halide such as ammonium chloride, etc.) of an acid, to give 3-methylcepham compound shown by the formula II. The reaction is preferably carried out in a solvent such as N,N-dimethylformamide, etc. in the presence of urea.
MASUGI TAKASHI
CHIBA TOSHIYUKI
YOSHIOKA AKITERU
UEDA IKUO
KOBAYASHI MASAKAZU
KATOU MASAYUKI
| JPS50105682A | 1975-08-20 | |||
| JPS4720188A |