Title:
PREPARATION OF (+)-ALPHA-HYDROXYMETHYLBUTYRIC ACID
Document Type and Number:
Japanese Patent JPS5765191
Kind Code:
A
Abstract:
PURPOSE: To prepare (+)-α-hydroxymethylbutyric acid by treating(±)-α-methyl- butyric acid with microorganisms belonging to Trichosporon genus.
CONSTITUTION: (±)-α-Methylbutyric acid is converted to (+)-α-hydroxymethyl- butyric acid by the aerobic cultivation of microorganisms belonging to Trichosporon genus, e.g. Trichosporon fermentans CBS2529 strain, in a medium containing ±- α-methylbutyic acid at 4.0W9.5pH. As an alternative method, (+)-α-hydroxy- methylbutyric acid is prepared by culturing the above microorganisms in a nutrient medium at 4.0W9.5pH, adding (±)-a-methylbutyric acid to the cultivation liquid or the suspension of the microorganisms obtained from the liquid, and reacting under aerobic conditions keeping the pH at 6.0W9.0.
Inventors:
HAMAGUCHI SHIGEKI
OGURA MASAHIRO
HASEGAWA JIYUNZOU
KAWARADA HAJIME
WATANABE KIYOSHI
OGURA MASAHIRO
HASEGAWA JIYUNZOU
KAWARADA HAJIME
WATANABE KIYOSHI
Application Number:
JP14025980A
Publication Date:
April 20, 1982
Filing Date:
October 06, 1980
Export Citation:
Assignee:
KANEGAFUCHI CHEMICAL IND
International Classes:
C12P7/42; C12P41/00; C12R1/645; (IPC1-7): C12P7/42