Title:
デルモピノールの調製
Document Type and Number:
Japanese Patent JP5726347
Kind Code:
B2
Abstract:
It comprises a process for the production of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by subjecting the compound of formula (II) where R1 and R2 are the same or different, independently selected from the group consisting of H, (C1-C6) alkyl or, alternatively, R1 and R2 form, together with the carbon atom to which they are attached, a (C5-C6) cycloalkyl radical; and R3 is a radical selected from the group consisting of CF3, (C1-C4) alkyl, phenyl, and phenyl mono- or disubstituted by a radical selected from the group consisting of (C1-C4)-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process.
Inventors:
Camry, Alexander
Hahne, Lawrence, Lafecas
Tesson, Nicola
Escale, Atoni, Riera
Hahne, Lawrence, Lafecas
Tesson, Nicola
Escale, Atoni, Riera
Application Number:
JP2014080739A
Publication Date:
May 27, 2015
Filing Date:
April 10, 2014
Export Citation:
Assignee:
Sinclair Pharmaceuticals Limited
International Classes:
C07C11/02; C07D265/30; C07C19/075; C07C217/08; C07D263/04; C07D303/04
Domestic Patent References:
| JP56156271A | ||||
| JP4500219A |
Foreign References:
| US3502627 |
Other References:
Kazuhiko Take et al.,Chem. Pharm. Bull.,1993年,Vol.41(3),p.507-515
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Katsuichi Nishimoto
Kato Kazunori
Katsuichi Nishimoto