Title:
２―（ω―アロイルアルキル）―４―ビアリール−オキソ酪酸によるマトリックスメタロプロテアーゼの阻害
Document Type and Number:
Japanese Patent JP3524556
Kind Code:
B2
Abstract:
The present invention provides pharmaceutical compositions and methods for treating certain conditions comprising administering an amount of a compound or composition of the invention which is effective to inhibit the activity of at least one matrix metalloprotease, resulting in achievement of the desired effect. The compounds of the present invention are of generalized formula (I) where nu is 1, 2, 3 or 4 and Ar represents a substituted aromatic moiety. These compounds are useful for inhibiting matrix metalloproteases and, therefore, combating conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from atherosclerotic plate rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.
Inventors:
ウィリアム ジェイ スコット
ディヴィッド エス ハートサウ
マーガレット エイ ポップ
ディヴィッド エス ハートサウ
マーガレット エイ ポップ
Application Number:
JP54119597A
Publication Date:
May 10, 2004
Filing Date:
May 12, 1997
Export Citation:
Assignee:
バイエル コーポレイション
International Classes:
A61K31/192; A61P7/02; A61P9/00; A61P13/12; A61P19/02; A61P19/08; A61P25/00; A61P27/02; A61P29/00; A61P35/04; A61P43/00; C07C45/00; C07C45/46; C07C45/63; C07C49/80; A61P1/04; C07C49/84; C07C59/84; C07C59/88; C07C59/90; C07C69/738; (IPC1-7): C07C59/88; A61K31/192; A61P1/04; A61P7/02; A61P9/00; A61P13/12; A61P19/02; A61P19/08; A61P25/00; A61P27/02; A61P29/00; A61P35/04; A61P43/00; C07C59/90
Attorney, Agent or Firm:
矢野 敏雄 （外２名）