To obtain a preventive and reductive agent against the generation of paralysis associated with ischemic reperfuration recognized after an operation requiring hemostasis of aorta, injection of aortic internal contrast media, or the like by using antithrombin-III of human origin as an active ingredient.
This preventive and reductive agent against the generation of paralysis associated with ischemic reperfuration recognized after a human or animal operation requiring hemostasis of aorta, e.g. the operation of thoracic descensus and thoracoabdominal aortic aneurysm, injection of aortic internal contrast media, or the like by using antithrombin-III of human origin as an active ingredient, and formulating a carrier, a vehicle, an additive such as a diluent, and a stabilizer such as saccharides such as a mannitol, a sorbitol and saccharose, an organic acid such as citric acid, malic acid and tartaric acid, or a salt thereof, and an amino acid such as aspartic acid and glycine, and forming the obtained mixture into a preparation.
HIROSE KOJI
TAOKA YUJI
