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Title:
PROCESS FOR PRODUCING PRAVASTATIN SODIUM SUBSTANTIALLY FREE OF PRAVASTATIN LACTONE AND EPI-PRAVASTATIN
Document Type and Number:
Japanese Patent JP2006036781
Kind Code:
A
Abstract:

To obtain a high-purity pravastatin sodium and to provide a novel process for purifying the pravastatin sodium.

This invention provides the high-purity pravastatin sodium with little pravastatin lactone and epiprava, and methods for isolating and purifying the pravastatin sodium by acid treatment and alkali treatment.


Inventors:
KERI VILMOS
DEAK LAJOS
FORGACS ILONA
SZABO CSABA
NAGYNE ARVAI EDIT
Application Number:
JP2005237299A
Publication Date:
February 09, 2006
Filing Date:
August 18, 2005
Export Citation:
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Assignee:
TEVA GYOGYSZERGYAR RT
International Classes:
A61P3/06; A61K31/19; C07C69/30; A61K31/22; A61K31/225; A61K31/365; A61P43/00; C07B53/00; C07C67/28; C07C67/52; C07C67/58; C07C67/60; C07D309/38; C12P7/42; C12P7/62; A61P9/00; C07D309/30
Domestic Patent References:
JP2003515334A2003-05-07
JP2006273861A2006-10-12
JP2000229855A2000-08-22
JPS5890509A1983-05-30
JPS5889191A1983-05-27
JP2003528576A2003-09-30
JP3737801B22006-01-25
Foreign References:
WO2000017182A12000-03-30
WO2000046175A12000-08-10
WO2000017150A12000-03-30
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji



 
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