Title:
E1活性化酵素阻害剤の合成のためのプロセス
Document Type and Number:
Japanese Patent JP5479336
Kind Code:
B2
Abstract:
The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1 S , 2 S , 4 R )-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
Inventors:
Armitage, Ian
Eliot, Eric Elle.
Marianne, Langston
Langston, Stephen Pee.
McBin, Quentin Jay.
Mizutani
Stealing, matthew
Chu, Ray
Eliot, Eric Elle.
Marianne, Langston
Langston, Stephen Pee.
McBin, Quentin Jay.
Mizutani
Stealing, matthew
Chu, Ray
Application Number:
JP2010519947A
Publication Date:
April 23, 2014
Filing Date:
August 01, 2008
Export Citation:
Assignee:
MILLENNIUM PHARMACEUTICALS, INC.
International Classes:
C07D487/04; C07C215/42; C07D303/48; C07D305/14; A61K31/519; A61P35/00; A61P43/00; C07B61/00
Domestic Patent References:
| JP2000290201A | ||||
| JP2009528986A | ||||
| JP2008530027A | ||||
| JP2003516962A |
Other References:
Tetrahedron,2006年,62(5),906-914頁
Collection of Czecholovak Chemical Communications,1976年,41(2),647-665頁
Journal of Medical Chemistry,1984年,27,534-536頁
Collection of Czecholovak Chemical Communications,1976年,41(2),647-665頁
Journal of Medical Chemistry,1984年,27,534-536頁
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita