PRODUCTION OF 1-PHENYL-1,3-PROPANEDIOL COMPOUNDS HAVING HIGH OPTICAL PURITY

Title:

PRODUCTION OF 1-PHENYL-1,3-PROPANEDIOL COMPOUNDS HAVING HIGH OPTICAL PURITY

Document Type and Number:

Japanese Patent JP3257050

Kind Code:

B2

Abstract:

PURPOSE: To effectively obtain an optically pure 1-phenyl-1,3-propanediol com pound useful as a raw material for tomoxetine, fluoxetine (antidepressant), etc., from the optically impure 1-phenyl-1,3-propanediol compound by a simple means.
CONSTITUTION: A R or S-1-phenyl-1,3-propanediol compound of the formula (X is halogen, 1-4C alkoxy) having an optical purity of 20 to <100%ee, preferably R or S-1-(phenyl, 4-fluorophenyl or 4-methoxyphenyl)-1,3-propanediol, is recrystallized in a solvent, preferably hexane, heptane, octane, cyclohexane, ethyl acetate, diethylether, benzene, toluene, methanol, ethanol, ethyleneglycol, water or their mixture, especially heptane, toluene or their mixture, to obtain the highly pure R or S-1-phenyl-1,3-propanediol compound having an optical purity of 100%ee.

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Inventors:

Kazutoshi Miyazawa
Mitsuyo Sugiura
Yasuyuki Koizumi
Naoyuki Yoshida

Application Number:

JP21666192A

Publication Date:

February 18, 2002

Filing Date:

July 23, 1992

Export Citation:

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Assignee:

Chisso Corporation

International Classes:

C07C29/78; C07C33/46; C07C43/23; (IPC1-7): C07C33/46; C07C29/78; C07C43/23

Domestic Patent References:

JP578277A
JP570406A
JP4260401A
JP3200753A
JP383936A
JP4717730A
JP1175956A
JP4258297A
JP6125789A

Attorney, Agent or Firm:

Eiko Funahashi

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