Title:
PRODUCTION OF ACETYLENE ALCOHOL COMPOUND
Document Type and Number:
Japanese Patent JP3203865
Kind Code:
B2
Abstract:
PURPOSE: To produce an acetylene alcohol compound useful as an intermediate for pharmaceuticals, agrichemicals and liquid crystals on an industrial scale at a low cost by asymmetrically hydrolyzing an acetylene alcohol ester compound using an esterase capable of preferentially hydrolyzing one of the optically active isomers of the ester compound.
CONSTITUTION: An optically active acetylene alcohol compound expressed by formula II [e.g. R(-)-6-heptyn-2-ol] and an optically active acetylene alcohol ester compound expressed by formula III [e.g (S)(+)-6-heptyn-2-ol butanoic acid ester] are produced on an industrial scale at a low cost by using an esterase capable of preferentially hydrolyzing either one of the optically active isomers of an acetylene alcohol ester compound of formula I [R" is (halogenated) 1-5C alkyl; (n) is integer of 2-6] (e.g. 6-heptyn-2-ol butanoic acid ester) and carrying out asymmetric hydrolysis of the ester component under vigorous agitation at 30°C for 14hr.
Inventors:
Naoyuki Takano
Takayuki Higashii
Masayoshi Nanai
Takayuki Higashii
Masayoshi Nanai
Application Number:
JP5873193A
Publication Date:
August 27, 2001
Filing Date:
March 18, 1993
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
International Classes:
C07B53/00; C07B57/00; C07C33/042; C07C69/24; C12P41/00; C12R1/06; C12R1/38; (IPC1-7): C12P41/00
Domestic Patent References:
| JP3247299A | ||||
| JP3259094A |
Attorney, Agent or Firm:
Takashi Kuboyama (1 person outside)