PRODUCTION OF HALOGENATED CYCLOPROPANE DERIVATIVE

Title:

PRODUCTION OF HALOGENATED CYCLOPROPANE DERIVATIVE

Document Type and Number:

Japanese Patent JPH09124556

Kind Code:

A

Abstract:

To stereo-selectively and efficiently obtain the subject optically active compound useful as an intermediate for producing new synthetic quinolone antibacterial agents by reacting a vinylidene halide with a diazo compound in the presence of a specific catalyst.

(B) A compound of the formula: CH2=CXF (X is Cl, Br, I) is reacted with (B) a compound of the formula: N2HCOR [R is a 1-10C alkyloxy (substituted with a halogen), an aralkyloxy comprising a (substituted)aryl and a 1-10C alkyloxy, a (substituted) aryloxy, a (halogenated aryloxy, a (halogenated) 1-10C alkylthio, an aralkylthio comprising a (substituted) aryl and a 1-10C alkylthio, amino, etc.; the substituent of the substituted aryl is a halogen, a 1-10C (halogenated) alkyl, etc.,] to preferentially produce the compound of the formula wherein the steric configuration of the 1-position is the S-configuration.

Inventors:

EHATA TSUTOMU
AKIBA TOSHIFUMI
IKETANI TAKANOBU
WAKITA RYUHEI
SASAKI MIKIO

Application Number:

JP983096A

Publication Date:

May 13, 1997

Filing Date:

January 24, 1996

Export Citation:

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Assignee:

DAIICHI SEIYAKU CO
SUMITOMO CHEMICAL CO

International Classes:

B01J31/16; C07B53/00; C07B61/00; C07C67/347; C07C69/74; C07C231/12; C07C231/18; C07C233/58; C07C255/56; C07C327/24; (IPC1-7): C07C69/74; B01J31/16; C07B53/00; C07C67/347; C07C231/12; C07C233/58; C07C255/56; C07C327/24

Attorney, Agent or Firm:

Masazumi Imamura (1 person outside)

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