Title:
PRODUCTION OF M-SUBSTITUTED-ALPHA-HYDROXYMETHYLSTYRENE DERIVATIVE AND 3-CHLORO-ALPHA-BROMOSTYRENE
Document Type and Number:
Japanese Patent JP3569877
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound capable of easily giving a m-substituted-α- hydroxymethylstyrene useful as an intermediate for herbicide, etc., in high yield.
SOLUTION: 3-Chloro-α-bromostyrene of formula I. The compound can be produced by reacting 3-chloro-α,β-dibromoethylbenzene of formula II or 3- chloro-α-dibromoethylbenzene of formula III with a base such as potassium hydroxide usually at 0-120°C for 5min to 2hr or by reacting 3-chloroacetophenone of formula IV with phosphorus tribromide preferably at 20-150°C for 30min to 5hr. The m-substituted-α-hydroxymethylstyrene is produced preferably by reacting 3-chloro-α-bromostyrene of formula I with metallic magnesium and reacting the resultant Grignard reagent with formaldehyde or paraformaldehyde.
Inventors:
Ken Tanaka
Manabu Katsura
Akemi Hosokawa
Manabu Katsura
Akemi Hosokawa
Application Number:
JP18172995A
Publication Date:
September 29, 2004
Filing Date:
July 18, 1995
Export Citation:
Assignee:
Nippon Pesticides Co., Ltd.
International Classes:
C07C17/18; C07C17/25; C07C22/04; C07C22/08; C07C25/28; C07C29/40; C07C33/30; C07C33/48; C07C41/26; C07C43/23; (IPC1-7): C07C25/28; C07C17/18; C07C17/25; C07C22/04; C07C29/40; C07C33/30; C07C33/48
Domestic Patent References:
| JP761945A | ||||
| JP2304043A |
Other References:
KAUFFMANN,T. et al.,Hohe Uberlegenheit der Reagenzien Me4CoLi2 und Me4FeLi2 im Vergleich zu Me2CuLi und Me4MnLi bei Kreu,Chemische Berichte,1992年,Vol.125, No.4,p.913-921
Attorney, Agent or Firm:
Calyx
Toshio Nakamura
Miyazaki Yoshio
Toshio Nakamura
Miyazaki Yoshio
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