Title:
PRODUCTION OF OPTICALLY ACTIVE ALCOHOLS
Document Type and Number:
Japanese Patent JP3675024
Kind Code:
B2
Abstract:
PURPOSE: To efficiently obtain the subject compound high in optical purity by treating the mixture of an optically active oxazaborolidine with a metal boron hydride as an inexpensive, easily available hydrogen source with an asymmetric ketone and an acid.
CONSTITUTION: The mixture of (A) an optically active oxazaborolidine of the formula (R1 is H, a lower alkyl, etc.; R2 to R5 are H, an aryl, etc.; R6 is H, a halogen, etc.; * is an asymmetric carbon atom) with (B) a metal boron hydride (preferably sodium boron hydride) is treated with (C) an asymmetric ketone [e.g. a compound of formula: R7CO-R8 (R7, R8 are an alkyl, an aryl, etc.)] and (D) an acid (e.g. sulfric acid). The components C and D are dropwisely added to and simultaneously reacted with the mixture of the components A and B. The dropping time is usually 0.1-20hr, and the mixture is preferably stirred at the temperature for 0.1-10hr, after the components are dropped.
Inventors:
Yukio Yone
Takeo Suzukamo
Takeo Suzukamo
Application Number:
JP6982396A
Publication Date:
July 27, 2005
Filing Date:
March 26, 1996
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
International Classes:
C07B31/00; C07B53/00; C07C29/143; C07C31/02; C07C31/135; C07C33/20; (IPC1-7): C07C29/143; C07B31/00; C07B53/00; C07C33/20
Domestic Patent References:
| JP7109231A | ||||
| JP7503734A | ||||
| JP8506345A | ||||
| JP6340674A |
Attorney, Agent or Firm:
Takashi Kuboyama
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