PURPOSE: To obtain a new repandiol and its derivative, having excellent antitumor activity and useful as a medicine.
CONSTITUTION: The objective repandiol and its derivative of formula I (R1 is H or lower acyl), e.g. (2R, 3R, 8R, 9R)-4,6-decadiyn-2,3:8,9-diepoxy-1,10-diol. The repandiol and its derivative of formula I are obtained by reacting a new compound of formula II (R2 is alkyl) with a reducing agent and then reacting the resultant new compound of formula III with an oxidizing agent. The compound of formula I is obtained by extracting a fruit body of Hydnum repandum Fr. and Hydnum repandum var. album Quel which are edible mushrooms with a lower alcohol, extracting the prepared extracted essence with an organic solvent and isolating the compound. Furthermore, the compound of formula I (R1 is H) is named the repandiol.
TAKAHASHI AKIRA
ENDO TAKESHI
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