Title:
血管形成及び心臓血管新生の促進又は阻害
Document Type and Number:
Japanese Patent JP4297317
Kind Code:
B2
Abstract:
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Inventors:
Ashkenazi, Avi, J.
Baker, Kevin, Pea.
Ferrara, napoleon
Gerber, Hands Peter
Geritzen, Mary, Yi.
Goddard, Audrey
Godovsky, Paul, J.
Gurney, Austin, Elle.
Kuo, Sofia, S.
Mark, Melanie, Earl.
Marsters, Scott, A.
Paoni, Nicholas, F.
Pitti, Robert, M.
Watanabe, Colin, Kay.
Williams, Pea., Mickey
Wood, William, Eye.
Baker, Kevin, Pea.
Ferrara, napoleon
Gerber, Hands Peter
Geritzen, Mary, Yi.
Goddard, Audrey
Godovsky, Paul, J.
Gurney, Austin, Elle.
Kuo, Sofia, S.
Mark, Melanie, Earl.
Marsters, Scott, A.
Paoni, Nicholas, F.
Pitti, Robert, M.
Watanabe, Colin, Kay.
Williams, Pea., Mickey
Wood, William, Eye.
Application Number:
JP2001500757A
Publication Date:
July 15, 2009
Filing Date:
May 17, 2000
Export Citation:
Assignee:
GENENTECH,INC.
International Classes:
C12N15/09; G01N33/50; A61K38/00; A61K38/17; A61K39/395; A61K45/00; A61P9/00; A61P9/10; A61P17/02; A61P27/02; A61P35/00; C07K14/47; C07K14/52; C07K16/18; C07K16/46; C07K19/00; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N9/99; C12N15/11; C12N15/12; C12N15/86; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/577; C12R1/91
Foreign References:
| WO1999025834A1 | ||||
| WO1998007880A1 |
Other References:
Genome Res., Vol.6, No.9,1996年,Vol.6, No.9,p.791-806
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori