Title:
アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断
Document Type and Number:
Japanese Patent JP6950981
Kind Code:
B2
Abstract:
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
Inventors:
Michal Novek
Eva koncekove
Branislav Kovacek
Norbert Zirca
Eva koncekove
Branislav Kovacek
Norbert Zirca
Application Number:
JP2019228943A
Publication Date:
October 20, 2021
Filing Date:
December 19, 2019
Export Citation:
Assignee:
Axon Neuroscience S.A.
International Classes:
C12N15/13; A61K9/08; A61K9/12; A61K9/19; A61K31/7088; A61K38/08; A61K38/10; A61K38/16; A61K38/17; A61K38/19; A61K38/20; A61K38/21; A61K38/38; A61K39/39; A61K39/395; A61K45/00; A61K47/68; A61K48/00; A61K49/00; A61K49/06; A61K49/16; A61K51/00; A61K51/10; A61P25/00; A61P25/02; A61P25/28; A61P43/00; C07K7/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/63; C12P21/08; G01N33/53
Domestic Patent References:
| JP2003508788A | ||||
| JP2004532817A |
Foreign References:
| WO2011026031A1 |
Other References:
Taniguchi, T., et al.,Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation,FEBS Letters,2005年,579,1399-1404
Ueno, H., et al.,Novel conformation-sensitive antibodies specific to three- and four-repeat tau,Biochemical and Biophysical Research Communications,2007年,358,602-607
Jicha, G., et al.,Sequence Requirements for Formation of Conformational Variants of Tau Similar to Those Found in Alzheimer's Disease,Journal of Neuroscience Research,1999年,55,713-723
Skrabana, R., et al.,Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423,FEBS Letters,2004年,568,178-182
Ueno, H., et al.,Novel conformation-sensitive antibodies specific to three- and four-repeat tau,Biochemical and Biophysical Research Communications,2007年,358,602-607
Jicha, G., et al.,Sequence Requirements for Formation of Conformational Variants of Tau Similar to Those Found in Alzheimer's Disease,Journal of Neuroscience Research,1999年,55,713-723
Skrabana, R., et al.,Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423,FEBS Letters,2004年,568,178-182
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto