Title:
Pyrazolo [4 and 3-d] pyrimidine useful as a kinase inhibitor
Document Type and Number:
Japanese Patent JP6222776
Kind Code:
B2
Abstract:
The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.
Inventors:
Michael Almstedter
Michael Tolman
Andreas Tremul
Nadine Traube
Michael Tolman
Andreas Tremul
Nadine Traube
Application Number:
JP2014505544A
Publication Date:
November 01, 2017
Filing Date:
April 23, 2012
Export Citation:
Assignee:
ORIGENIS GMBH
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61K31/541; A61P1/00; A61P7/00; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/00; A61P15/00; A61P17/00; A61P17/04; A61P19/02; A61P19/08; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| JP59196892A | ||||
| JP2008247907A |
Foreign References:
| EP1348707A1 | ||||
| US6531475 | ||||
| WO2002074774A1 | ||||
| WO1998029413A1 | ||||
| US20030139427 | ||||
| EP2123654A1 |
Other References:
Yuan, Jun et al.,3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: non-peptide CRF-1 antagonists,Bioorganic Medicinal Chemistry Letters,2002年 1月 1日,vol.12 no.16,pp.2133-2136
Attorney, Agent or Firm:
Osamu Hatori
Yoshiyuki Matsushima
Akihisa Iwamoto
Hiromi Nakano
Genichi Naruse
Yoshiyuki Matsushima
Akihisa Iwamoto
Hiromi Nakano
Genichi Naruse