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Title:
PYRIDINECARBOXIMIDAMIDE COMPOUND AND ITS USE
Document Type and Number:
Japanese Patent JPH07188172
Kind Code:
A
Abstract:

PURPOSE: To obtain the subject new compound, having strong vasodilator actions and useful as a vasodilator for treating diseases of hypertension, angina pectoris, cardiac failure and cerebral circulation disorder.

CONSTITUTION: This compound is expressed by formula I [R1 is a lower alkyl, an aralkyl, hydroxyl group, a lower alkoxy, nitro, etc.; R2 is an aryl which may be substituted by one or more halogens or lower alkyls or nitroxyl; R3 is H or amino; (n) is an integer of 2-4] and its acid addition salt, e.g. N-acetyl-N '-phenethyl-3-pyridinecarboximidamide expressed by formula II or N-benzoyl-N'- phenethyl-3-pyridinecarboximidamide expressed by formula III. The compound expressed by formula I is obtained by passing, e.g. a compound expressed by formula IV (R4 is a lower alkyl) as a starting raw material through a compound expressed by formula V.


Inventors:
NAKAJIMA YOSHIYA
NAKAJIMA TATSUO
Application Number:
JP34873993A
Publication Date:
July 25, 1995
Filing Date:
December 27, 1993
Export Citation:
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Assignee:
KIRIN BREWERY
International Classes:
C07D213/78; A61K31/44; A61K31/4406; A61P9/08; (IPC1-7): C07D213/78; A61K31/44
Attorney, Agent or Firm:
Kazuo Sato (2 outside)